Post-encephalitic Parkinsonism: current experience.

Adolf Hitler had post-encephalitic Parkinsonism.

Adolf Hitler had Parkinson symptoms in 1934, at age 45 years. He may have had transient symptoms in 1923, at age 34 years. Young-onset parkinsonism, during the 1920s, favored a diagnosis of post-encephalitic rather than idiopathic parkinsonism. Hitler had oculogyric crises, phenomena only associated with post-encephalitic parkinsonism. In addition, he had dystonic facial spasms, palilalia and a...

Post-encephalitic parkinsonism with amyotrophy.

The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans.

The hyaline inclusions in the pigmented ganglion cells of the substantia nigra and the locus coeruleus in patients suffering from idiopathic paralysis agitans are known as Lewy bodies after their discoverer, Lewy (1913). A detailed description of these bodies was presented by Greenfield and Bosanquet in 1953. The intracytoplasmic bodies are always surrounded by a light halo, and often have a ce...

Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by Japanese encephalitis virus.

Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has an important role in the control of neurotransmitter concentration. We previously reported that exogenously administered isatin significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. In order to test the possibility of treating Parkinson's disease by isatin, we evaluated DA levels in the striatum and...

Chlorpropamide in Parkinson's Disease

disease includes the following observations, but their significance is not yet clear: (1) There is evidence of a connection between abnormal glucose tolerance and post' encephalitic Parkinson's disease (Gillhespy and Paton, i960; Terrana and Adragn^ 1951). McCowan, Harris and Mann (1926) give glucose tolerance curves for a group of patients with post-encephalitic Parkinsonism which are clearly ...